ABSTRACT
Over the past two decades, substantial changes in the epidemiology of pathogens in CF patients have been described.1 e etiologies of these changes are most likely multifactorial. Potential explanations include improved clinical microbiology laboratory methods, molecular identication strategies, changes in taxonomy, increased life expectancy, selective pressure from antimicrobial agents, potential changes in the natural environment, and/or patient-to-patient transmission. Classic CF pathogens and emerging pathogens that are oen highly resistant to antimicrobial agents are shown in Table 13.1. Furthermore, recent work exploring the microbiome in CF has revealed organisms not generally thought to be associated with CF lung disease, particularly anaerobic microorganisms.2-4 e microbiome in CF is discussed further in Chapter 14.
