ABSTRACT
Paracoccidioidomycosis (PCM), is a systemic mycosis with clinical manifestations of a granulomatous disease, caused by thermally dimorphic Paracoccidioides spp. Adolpho Lutz fi rst described it in 1908, while examining oral lesions in two patients. The fi rst patient, a Spanish man, 40 years old, reported oral lesions for six months and the second patient, a 30 year old man, reported a four-year history of multiple oral lesions. Five months later, Lutz reported that the patient returned quite emaciated, with hoarseness and diarrhea (Reviewed by Marques 2008). Primarily named as “pseudococcidial hyphoblastomycosis” (pseudococcidial to differentiate from coccidioidomycosis and hifoblastomycosis), the mycosis was then called South American Blastomycosis or Lutz and Splendore-Almeida disease (Lacaz et al. 1991). The actual term Paracoccidioidomycosis was established in 1971 in Medellín, Colombia, during a meeting of the American Continent mycologists and has been widely accepted since then (Lacaz 1982).
