Vitiligo is an acquired pigmentation disorder characterized by loss of pigment of the skin, mucosa, or hair due to destruction of melanocytes. The goals of vitiligo treatment are repigmentation and cessation of depigmentation. A combination of treatments is often utilized to provide as much repigmentation as possible. Studies have shown that 70%–80% of patients will regain partial repigmentation with treatment, but only 20% will regain full pigmentation.1 Repigmentation occurs in a perifollicular pattern, usually from the edges of the lesions. Although there is no one optimal treatment for vitiligo, a combination of rst-and second-line topical and oral treatments provides many patients with adequate repigmentation. There are continually new treatments being developed which may further improve repigmentation in combination with traditional medical therapy. This chapter reviews a wide range of available therapies and outlooks for the future in the treatment of vitiligo.