ABSTRACT
The purpose of this chapter will be to summarize clinicopathologic features, and signifi cant issues in the pathogenesis of cerebral amyloid (congophilic) angiopathy (CAA). This entity is less frequently also described as cerebrovascular amyloidosis (thus confusingly abbreviated as ‘CVA’). Several excellent reviews and a book published within recent years have dealt with the molecular genetic, cellular and biochemical pathogenesis and consequences of both sporadic and familial forms of CAA (Rensink et al. 2003, Revesz et al. 2003, 2009, Attems et al. 2011, Verbeek et al. 2000); this chapter will not attempt to recapitulate detailed analysis of these crucial issues but will highlight fi ndings that relate to the consequences of CAA for the brain. Neither will we attempt to review the extensive literature on molecular aspects of
1 Departments of Pathology & Laboratory Medicine (Neuropathology) and Neurology, Brain Research Institute and Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CALIFORNIA, USA.
