ABSTRACT
Introduction ................................................................................................................................. 268 Cell lines (human, mouse, rat) as model for biomedical research ....................................... 270
Human cell lines ..................................................................................................................... 270 Tumor cell lines ....................................................................................................................... 270
Human epithelial carcinoma cell line A549 ................................................................... 270 Human bladder carcinoma cell lines and human broblast IMR90 cell lines .......... 270 SH-SY5Y human neuroblastoma cells ............................................................................ 271
Mouse cell lines ...................................................................................................................... 272 Murine 3T3-L1 cell line ..................................................................................................... 272 Other mouse cell lines ....................................................................................................... 272
Rat cell lines ............................................................................................................................ 272 PC12 cell line ...................................................................................................................... 272 Rat C6 glioma cell lines ..................................................................................................... 273 Other rat cell lines ............................................................................................................. 273
Transgenic monkey model ......................................................................................................... 273 Monkey model and Huntington disease ............................................................................ 274 Method of transgenesis ......................................................................................................... 275 Production of transgenic HD monkeys by lentivirus ....................................................... 275 Generation of HD monkey ES-like cells by induced pluripotency ................................. 275 Monkey model and schizophrenia ...................................................................................... 275 Monkey model and autism ................................................................................................... 276 Monkey model and heart disease ........................................................................................ 276
Transgenic rat model .................................................................................................................. 276 Rat model and obesity ........................................................................................................... 276 Rat model and hypoxic brain damage ................................................................................ 278
Transgenic rat model and antiepileptic drug production ..................................................... 278 Enhancement of GABA action .............................................................................................. 278 Inhibition of sodium channel function ................................................................................ 278 Inhibition of calcium channels ............................................................................................. 279 Other mechanisms.................................................................................................................. 279 Engineered rat model of antiepileptic drugs ...................................................................... 279
The kindling process ................................................................................................................... 279 Properties of kindling ............................................................................................................ 279
Porcine xenotransplantation ............................................................................................280 Organs for xenotransplantation ......................................................................................280
