Nanotechnology has the potential to revolutionize the medical

profession by improving on traditional drug delivery methods

and transforming how disease and injury are currently diagnosed,

monitored, and treated. The effective delivery of small-molecule

drugs, peptides, and proteins to a site of disease or injury has

faced considerable barriers in the past. These include premature

clearance from the body, off-site toxicity, and poor bioavailability or

pharmacokinetics. Nanoparticles can be used to help improve these

characteristics by aiding delivery of therapeutics that otherwise

show little efficacy without assisted delivery. This chapter contains

two separate yet highly related sections. The first section will

provide a review and introduction to the field of nanoparticles

developed for drug delivery. This introduction will cover a range

of different nanoparticle formulations and their associated merits

and pitfalls. The second portion will provide an insight into some

of our research on the development and characterization of a

multifunctional poly(glycidyl methacrylate) (PGMA) nanoparticle

system designed for therapeutic delivery. Here we show this multi-

functional nanoparticle system and its ability to effectively deliver

a therapeutic peptide designed to modulate L-type calcium channel

activity following cardiac ischemia-reperfusion injury. These results

have broad applicability beyond the treatment of this injury into a

range of disease and injury sites that require rapid cellular delivery

of an appropriate therapeutic payload. This nanoparticle system

provides sound proof-of-concept for peptide delivery ex vivo. With

further testing it has the potential to change how we currently treat

one of the major contributors to cardiac failure.