ABSTRACT
Protein folding in vivo is a complex process that depends on the interaction of the polypeptide with a wide range of proteins organized in macromolecular machineries acting as protein quality control systems (Balch et al. 2008; Powers and Balch 2013; Powers et al. 2009). is complex network comprises over 1000 proteins and is responsible for protein synthesis, folding, tracking, and degradation (Calamini et al. 2011; Hartl et al. 2011; Powers and Balch 2013; Powers et al. 2009). e protein quality control system allows adaptation of the cell to various intrinsic or environmental challenges, such as genetic mutations and thermal or oxidative stress (Balch et al. 2008; Powers and Balch 2013; Powers et al. 2009). Nevertheless, a single genetic mutation may impact protein folding ability substantially and thus lead to a loss-of-function conformational disease (Balch et al. 2008; Martinez et al. 2008; Muntau et al. 2014; Pey 2013; Powers et al. 2009).
