ABSTRACT
CLASSICAL TUBERCULOID GRANULOMA 1. e initial response to infection with Mycobacterium tuberculosis
(MTB) is the formation of a granuloma. a. A granuloma is an organised collection of activated macrophages. b. Macrophages dierentiate from monocytes and are the most eec-
tive phagocytic cells in the body. c. A macrophage is ‘activated’ by cytokines (predominantly
interferon-γ [IFN-γ]) in response to the antigen (in this case, antigen triggers from MTB).
