This chapter presents a quick overview of some key concepts and perspectives that dominate the human factors/ergonomics (HFE) field in the energy industries. It describes different methods representative of the literature of HFE in energy. The chapter also describes a possible application of the verification and validation method in an industry case of safety review of a nuclear power plant control room. The goal of this HF safety review was to assess whether the HFE design fulfills requirements such as design principles, guidelines, and standards, allowing the control room crew to achieve the plant's safety and operational goals in an efficient way. The chapter suggests that the control room function was acceptable, since most identified human engineering discrepancies could not be attributed to HSI characteristics and were not systematic. Human-computer interaction encompasses knowledge from various disciplines, including cognitive science, behavioral science, design, media studies, and computer science.