ABSTRACT
In the characterization of powdered materials, solubility and dissolution rate are important properties. These properties may become critical when a powdered material is used as a solution or when it can work effectively in a molecular form in solution. Like solubility, the dissolution rate is also important in considering particle design from a practical point of view, and many researchers have characterized the dissolution rate. Micronization is one of the simplest and most popular methods of improving the solubilizing properties of materials. Co-grinding the poorly water soluble drugs with hydrophilic additives is an effective way to increase the dissolution rate of micronized particles of materials having poor water solubility. Complex formation of a material with some other molecule sometimes changes an apparatus’s solubility. Higher solubility is expected for a solute in an amorphous form. A list of the solubility ratios of amorphous drugs compared to those of the crystalline form.
