ABSTRACT
This chapter introduces the theory of kinetics on nucleation and growth that determines particle morphology are introduced and presents an application. The crystallization operation has been used as a salt production method since a long ago, but also in modern industrial production it plays an important role as the solidification technology mainly of pharmaceuticals and foods. Crystallization is recognized as a particle production technique in liquid phase. The precipitation occurs through nucleation and growth in microscopic description of the crystallization processes. The growth after the nucleation is a molecular kinetic and transfer process of the solute molecules, and then it is a phenomenon handled separately from nuclei generated by fluctuation at the initial stage of the non-equilibrium phase transformation. The control of the particle morphology by using the crystallization process mainly concerns particle size distribution, particle shape and polymorphic control. The shape of a crystal in the thermal equilibrium state has only one structure and is distinguished from the non-equilibrium state.
