ABSTRACT
Abstract ................................................................................................. 308 12.1 Introduction ................................................................................ 308 12.2 Foley Catheter ............................................................................ 309 12.3 Invaders of Foley Catheter ......................................................... 310 12.4 Stages in Crystalline Biofilm Formation ................................... 312 12.5 Nano Weapons to Control Catheter Blockage ........................... 325 12.6 Future Scope .............................................................................. 331 Keywords .............................................................................................. 331 References ............................................................................................. 331
R. MALA* and A. S. RUBY CELSIA
Department of Biotechnology, Mepco Schlenk Engineering College, Sivakasi 626005, Tamil Nadu, India
*Corresponding author. E-mail: maalsindia@gmail.com
ABSTRACT
Catheter-associated urinary tract infection (CAUTI) is a major hospitalacquired infection. Millions of people suffer from this disease annually. Proteus mirabilis is a dimorphic organism that is predominantly associated with crystalline biofilm formation and encrustation in urinary catheter. This review addresses the orchestral performance of P. mirabilis with various virulence factors in the process of encrustation. The influence of pH on the shape and planes of struvite crystals were elaborated. It explores how silver and other nano weapons are exploited to win over the micro enemy by targeting the different stages of crystalline biofilm formation. The mechanism of silver nanomaterial in reducing the biofilm and its limitations are also discussed. The advantages of functionalizing Foley catheter with an array of bioactive compounds by layer-by-layer assembly was emphasized in nutshell.
