This chapter discusses “random laser” devices based on organic materials. It describes the use of semiconductor materials for optoelectronics and photonics devices in terms of physical–chemical properties, characteristics, and advantages. The chapter explains the self-organization and lithographic processes are described for the realization of nanoscale organic random lasers. It explores the random-laser emission from scattering nanoaggregates of a thiophene-based molecule, obtained in a controlled way by a simple soft-lithography technique. The chapter describes a random laser with desired shape, where the scattering centers are thiophene aggregates formed by spontaneous molecular self-assembly guided by surface tension-driven (STD) lithography. A laser is made of three basic elements: a pump source, a material that provides optical gain, and an optical cavity, e.g., two mirrors in the most simple configuration, which trap the light. The fundamental parameters describing this process are the mean free path and the diffusion constant.