This chapter provides an overview of legislations and regulations related to site remediation. Besides the overarching objectives of site remediation to protect human health and the environment, the implementation of site remediation relies on regulatory framework and guidelines. Resources Conservation and Recovery Act covers hazardous waste management from a preventive perspective. It addresses the hazardous waste management responsibilities of all involved entities, including generators, facilities. The Comprehensive Environmental Response Compensation (CERCLA) and Liability Act liability is retroactive, so any party could be found responsible for contamination that occurred before CERCLA's enactment in 1980. A brownfield is a property whose expansion, redevelopment, or reuse may be complicated by the presence or potential presence of a hazardous substance, pollutant, or contaminant. The Clean Water Act of 1972, which is actually an amendment to the Federal Water Pollution Act of 1948, is arguably the most important and most influential federal law in the recent history of the United States.