50Heavy metal toxicity is one of the abiotic stresses that cause deleterious health effects both in animals and plants. Owing to their higher reactivity they directly affect growth, development, senescence and energy synthesis process. The signaling network eventually leads to transcriptional activation of metal-responsive gene to combat the stress. Sorghum is one of the most important staple foods for the world’s poorest and most foodunsecured people across the semi-arid tropics. Root system of Sorghum vulgare is fibrous in nature, which leads to accumulation of metals more in the root. But interestingly, grains of the plant remain free from contamination because transfer and transportation ratios remain low for the metals within the plants under field condition.