ABSTRACT

YVONNE YEUKAI MUREVANHEMA, VICTORIA ADAORA JIDEANI, and OLUWAFEMI OMONIYI OGUNTIBEJU

5.1 Introduction .................................................................................. 102 5.2 Seeds and Value-Added Products of Bambara Groundnut .......... 105 5.3 Traditional Therapeutic Uses of BGN ........................................ 107 5.4 Nutritional Link to Therapeutic Effects ...................................... 109 5.5 Phenolic Phytochemical Structure ................................................111 5.6 Phenolic Phytochemicals in BGN ................................................113 5.7 BGN Antioxidant Defense Network .............................................117 5.8 Assessment of Antioxidant Capacity In Vitro and In Vivo ...........118 5.9 An Etiology of Inflammatory Activities ..................................... 124 5.10 Progression to Chronic Inflammation ........................................ 125 5.11 Biomarkers or Indicators of Inflammation ................................. 126 5.12 Mitigation of Pro-Inflammatory Biomarkers ............................ 128 5.13 Oxidative Stress: Regulated and Unregulated Systems ............. 131

5.14 Oxidative Stress: Biomarkers .................................................... 134 5.15 Oxidative Stress: Management ................................................. 138 5.16 Conclusions ................................................................................ 139 5.17 Summary .................................................................................... 139 Keywords .............................................................................................. 140 References ............................................................................................. 141

5.1 INTRODUCTION

Socio-economic and health-related issues, including climate change and premature death associated with life-style degenerative diseases, have recently become a state of urgency. Erratic rainfall, attributed to climate change, is a threat to food security [27]. Bambara groundnut (Vigna subterranea (L.) Verdc) (BGN) is one of the drought-tolerating crops, and it is envisaged to be the food of the future.