Genomic selection (GS) proposed by Meuwissen in 2001 does have a potential to emerge as a solution to the limitations of traditional marker-assisted selection (MAS). The use of MAS in plant breeding has continued to increase in the public and private sectors. GS is emerging as a promising molecular breeding tool for crop plants and has potential to minimize the negative effect of complex traits in estimating the breeding value. The genomic sequence information of the major food crops have been deciphered and populated in the publicly available genomics database. Wheat is a polyploid crop that consists of several homologous chromosomes and has a very large genome size of 17 Gb. Sorghum is an important food and fodder crop, now emerging as a potential biofuel crop. Maize is utilized as a staple food and animal feed and as a fuel. Global demand for maize is increasing, and huge efforts have been made for yield and quality improvement.