ABSTRACT
Recent advancements and progression in the field of nanobiotechnology precedes production and modulation of metal nanoparticles as well as nanomaterials, which have diverse applications in the areas like biomedicine, agriculture, optics and environment. Many physical and chemical procedures are employed for the synthesis of metal nanoparticles, but they have their own drawbacks like extravagance, biotoxicity, and environmental pollution. Biogenic green synthesis of MNPs serves an alternative potential way for convenient, economical, sustainable and eco-friendly synthesis of MNPs. Biogenic processes do not require high energy or harsh and toxic chemicals. Thus living systems, including algae, fungi, bacteria, viruses, plants and human cell lines, can be employed as sustainable nanofactories.
In the present scenario multidrug resistance (MDR) is a challenging obstacle in bacterial infection therapies. MDR bacteria can cause chronic infections. Because of their fminute size and high surface area, these MNPs can penetrate into the highly impermeable plasma membrane of MDR bacteria.
Plant-originated MNPs can serve as potential weapon against MDR bacteria. Biosynthesis of MNPs brings about binding of bioactive compounds to the MNPs which in turn enhances their biocidal action against MDR bacteria. This study is based on plant-mediated green synthesis of MNPs and their significant therapeutic biomedical application against MDR bacteria. This study also summarized recent advancements and future prospects with reference to some important medicinal plants.
