ABSTRACT
Sarcopenia is an age-related decline in muscle mass and strength. With a high prevalence—10% of the elderly suffer from sarcopenia globally—urgent initiatives are warranted to manage and cope with sarcopenia. The recommended therapeutic regimens include exercise therapy, hormone replacement and nutraceutical interventions, individually or in combination. Plant flavonoids have diverse biological activities central to sarcopenia management—anti-inflammatory, regenerative, antioxidant—and are thus under various investigational studies to establish their key role in promoting muscle health. The present review discusses the recently reported mechanism-based pre-clinical and clinical studies investigating the myoprotective nature of flavonoids in sarcopenia.
