ABSTRACT
Cancer remains a global health issue affecting millions of people worldwide, even after advancements in research, diagnosis, and prognosis of the disease. One of the main difficulties in cancer chemotherapy is preventing multidrug resistance and preserving medication circulation. Natural ingredients, herbs, and spices have been utilized to prevent various ailments, including cancer. Some of the natural products, such as curcumin, EGCG, resveratrol, genistein, sulforaphane, lycopene, indole-3-carbinol, and gingerol, have shown their potential in cancer chemoprevention. The limitations of using natural products, including their poor solubility, low oral bioavailability, and ineffective systemic distribution, can be overcome by the developing science of nanotechnology. The use of nanoparticles in the form of nano-formulations is a great platform for incorporating various medications or active materials that may be delivered effectively to the intended action site without compromising the drug’s or material’s activity. Nano-formulations can be employed to distribute conventional natural compounds with low solubility or a short half-life. The inherent problems with natural products (stability, solubility, and toxicity) can be greatly reduced when conventional natural products are mixed with nano-formulations, which also provide a platform for targeted delivery to tumor sites. Encapsulating natural products within nanoparticles can increase the efficacy of cancer treatment.
