ABSTRACT
Cancer, being a prevalent cause of mortality all over the world, has become an area of major concern for researchers. The genetic and epigenetic variations modulate the expression of oncogenes, which leads to the transformation of normal healthy cells into malignant cells. A significant role of nutritional paucity has been observed in the progression of the tumor. Due to the recent advancements in the field of systems biology, it becomes possible to study the effect of nutrients (diet) on the individual’s genes and health with the help of omics technologies. The integration of systems biology with nutritional research gives rise to a new aspect of the research area—nutrigenomics or nutritional genomics. Nutrigenomics paves the way to unravel the mystery behind the association of nutrition with cancer chemoprevention. The aim of this chapter is to get an insight about the effect of dietary compounds in cancer chemoprevention in the context of nutrigenomics. Dietary compounds corroborate to have a direct or indirect effect on the expression of a particular gene. The association between diet and cancer is slightly intricate. However, nutrigenomics fosters the advancements in understanding the nutritional framework of cancer chemoprevention and paves the way toward personalized treatments.
