ABSTRACT
In recent years, nanotechnology has made significant breakthroughs in the field of oncology. chemotherapeutic treatments are not precise toward the cancerous cells, and they may often destroy healthy cells as well, causing a slew of side effects. Because of the nonspecific targeting, low doses of chemotherapeutic drugs make cells chemoresistant, while excessive doses could kill healthy cells. Deep understanding of nanomaterials may hold the key to improving cancer medicine tailoring and delivery. Cancer diagnosis and management can be improved by converting pharmacological and natural drugs into nano-based products. The present chapter highlights the insights of characteristics, synthesis methods, cellular uptake, safety issues, and challenges of different of nano-formulated chemotherapeutic drugs. Liposomes, polymeric micelles, dendrimers, and inorganic nanoparticles are examples of novel nano-formulations that have been proven to enhance and specify drug delivery in recent times. Chemotherapeutic drugs are more effectively delivered to cancer cells via these carriers. The challenges associated with nano-formulation of chemotherapeutic drugs to optimize uptake and effectiveness are significant. Three important elements that need to be considered while manufacturing nanodrugs are drug integrity, transport, and breakdown mechanisms along with FDA quality restrictions. Nano-formulations of medicines should keep rising in popularity as nanomedicine proves its worth and authenticity.
