ABSTRACT
Black cumin (Nigella sativa) is an annual blooming plant in the Ranunculaceae family that is widely used throughout the entire globe. It is extensively utilized in a variety of traditional medical systems, including Ayurveda, Unani, and Siddha, due to various major active compounds such as thymoquinone, thymohydroquinone, dithymoquinone, p-cymene, carvacrol, 4-terpineol, t-anethol, and thymol. The most significant of these is thymoquinone, which has several pharmacological effects. For thousands of years, the seeds of black cumin have been used to cure a variety of ailments. The significance of this plant’s seeds was highlighted in Islamic literature. It’s often used as an antioxidant, anticancer, antidiabetic, antihypertensive, diuretic, digestive, antidiarrheal, analgesic, antibacterial, and immunomodulator, as well as for skin diseases. Many research investigations have been conducted on this plant, and these studies have looked into a range of antidiabetic potential. The presence of thymoquinone, a main active ingredient of the volatile oil, has also been discovered to be a key medicinal application of this plant in research investigations. The purpose of this study is to highlight the antidiabetic features of N. sativa with its potential mechanisms of action.
