ABSTRACT

Introduction In Caucasians cystic fibrosis (CF) is the most frequent inherited life-limiting disease. It affects multiple organs. Respiratory and gastrointestinal complications are the predominant manifestations, the former being the cause of death in over 90% of affected individuals. In the past, life expectancy was very low. Improvement in treatment and care in specialised centres led to a considerable rise in survival. This has raised new questions regarding future choices not only for study and career, but also about fertility, reproduction and parenthood.