ABSTRACT
Prognosis has been well defined for patients with soft tissue sarcoma. Several fundamental concepts are important. Soft tissue sarcomas are diverse, but tend to behave in a similar fashion when grouped together. Outcome variables must be carefully selected in terms of analyzing the impact of prognostic factors. Despite the evolution of several newer molecular markers and technologies, the best variables defining prognosis remain size, site and grade. The endpoints defining prognosis include local recurrence, metastatic recurrence, and tumor mortality. The relationship between these endpoints is complex and is certainly, at least in part, site-dependent.
