ABSTRACT
The majority of patients with extremity sarcoma present with a painless lump (Figure 4.1). A minority present with late-stage disease, including a fungating tumor (Figure 4.2) or an advanced posterior scapula lesion (Figure 4.3) or undifferentiated sarcoma in
the presence of lymphedema (Figure 4.4). Differential diagnosis includes a multitude of benign and potentially malignant lesions. The most common benign lesion is a lipoma, and the factors that suggest a soft tissue sarcoma in the presence of a clinically lipomatous mass
Figure 4.1 The majority of patients present with a painless lump: (a) atypical lipomatous tumor of the posterior thigh; (b) schwannoma of foot; (c,d,e) lipoma of right thigh; (f) low-grade malignant fibrous histiocytoma (MFH) invading bone.
