ABSTRACT
The previous failure in the 1970s and 1980s of lung cancer screening trials (comparing chest radiography alone or in combination with sputum cytology)1-5 to demonstrate a mortality reduction benefit led to a consensus that screening for lung cancer was not warranted.6-8 More recently, detailed re-examination of these trial data identified serious flaws and limitations in the study design, so that the conclusions have been questioned.912 In addition, prospective cohort studies have demonstrated the potential benefits of lung cancer screening with low-dose spiral computed tomography (LDSCT).13-17 Interest in LC screening may be fueled by high levels of public interest and enthusiasm for screening in general.18
