ABSTRACT
One renal alteration that appears to be common to type 1 and type 2 diabetes is an early period of glomerular hyperfiltration [1-4]. Increased glomerular filtration rate (GFR) and renal plasma flow have been extensively documented in type 1 diabetes presage the onset of nephropathy [5]. Studies in experimental, insulin-deficient diabetes have shown that this hyperfunction is mainly due to glomerular hypertrophy and increased glomerular capillary pressure that are widely recognized as important factors in the genesis of glomerular injury [6-8]. Numerous studies have repeatedly shown an improvement or prevention of experimental diabetic glomerulosclerosis by normalizing intraglomerular pressure.
