ABSTRACT
With the discovery of the low-density lipoprotein (LDL) receptor by Goldstein and Brown our understanding of the cholesterol economy of the cell took a major step forward.1 Further breakthroughs by that team and others have now given us the framework to understand in detail the effects of a drug that manipulates and changes that finely balanced economy.2 The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or statins are an important group of drugs that have such an effect.
