ABSTRACT
Monotherapy with one of the statins does not always lower low-density lipoprotein (LDL) cholesterol and triglycerides or raise high-density lipoprotein (HDL) cholesterol to the required extent and it is sometimes necessary to combine their administration with other lipid-regulating drugs. For example, in severe familial hypercholesterolaemia (FH) even maximal doses of statins do not always lower LDL cholesterol sufficiently and an anion-exchange resin is often added. Also, in mixed dyslipidaemia, statin monotherapy may fail to reduce triglycerides and raise HDL cholesterol to the desired levels and it may be necessary to add either nicotinic acid (niacin) or a fibrate to achieve these objectives.
