ABSTRACT
Introduction Angiogenesis, the growth of new blood vessels, is essential during fetal development, female reproductive cycle, and tissue repair. In contrast, uncontrolled angiogenesis promotes the neoplastic disease and retinopathies, whereas inadequate angiogenesis can lead to coronary artery disease. Although unregulated angiogenesis is seen in several pathological conditions including psoriasis, nephropathy, cancer, and retinopathy, it is essential for embryonic development, menstrual cycle, and wound repair (1-7). The deregulated and excessive vessel growth can have a significant impact on health and contribute to various diseases, such as rheumatoid arthritis, obesity, and infectious diseases. However, it can also be therapeutic in the treatment of some diseases.
