ABSTRACT

There are many aspects of adrenal function which render this gland particularly susceptible to damage by toxins. In addition, the hormones of the adrenal gland, especially the steroids produced by the adrenal cortex, are an essential component of the physiological response to stress, and if adrenal function is impaired the consequences of toxic or other insult to the body are likely to be severe. This and the following chapter provide a summary of normal adrenal function, while giving an indication of why this tissue is vulnerable to toxicological assault, showing the importance of the corticosteroids in maintenance of homeostasis and describing the consequences of impaired adrenal function.