ABSTRACT
The purpose of this study was to assess the oral toxicity of PP 27567, a systemic inhibitor of acetyl-CoA:cholesterol acyltransferase (ACAT). Four groups of 20 male and 20 female Sprague-Dawley rats received daily oral doses of 0 (control), 5, 25 or 125 mg/kg PP 27567 for 3 months. Satellite groups of 6 males and 6 females per dosage level were included for determination of plasma drug levels. Parameters evaluated included clinical signs of toxicity, body weight and food consumption, plasma drug levels on days 1 and 88 of dosing at 2, 6, 10 and 24 hours after compound administration, mid-study and terminal hematology, clinical chemistry, urinalysis, organ weights, necropsy observations and histopathologic examination of principal tissues.
