ABSTRACT
In 1995, the International Restless Legs Syndrome Study Group described a set of minimal inclusion criteria for restless legs syndrome (RLS) consisting of four cardinal features: (1) desire to move the extremities, often associated with paresthesia/dysesthesia; (2) motor restlessness; (3) worsening of symptoms at rest and at least temporary relief with activity; and (4) worsening of symptoms in the evening or night1. Other features frequently associated with RLS include periodic limb movements while asleep (PLMS), a normal neurological examination, a tendency for symptoms to gradually worsen with age and improvement with dopaminergic treatments.
