ABSTRACT
In 1721 Antonio Vallisneri,1 an Italian scientist, described for the first time the clinical and anatomo-pathological features of polycystic ovary syndrome. In 1935, Irving F Stein and Michael L. Leventhal2 described a complex symptom associated with anovulation. They described seven patients with amenorrhea, hirsutism and enlarged ovaries. They reported that all the patients resumed normal menses after bilateral wedge resection of ovaries. Out of these seven patients, two became pregnant. They concluded that wedge resection overcome the mechanical barrier produced by the thickened tunica which otherwise prevented follicles from reaching the ovarian surface and thus ovulating. The concept of wedge resection came from the observation that some of their patients resumed menstruation after ovarian biopsy.
