ABSTRACT
Autologous fat has been used as a filler for soft tissue defects for the past two centuries (1). As early as 1893, Neuber reconstructed a facial defect with fat. He felt that the fat survives as tiny parcels of tissue (1). Erich Lexer, in 1910, described repairing depressions status postfacial fractures with autologous fat; he performed studies that showed that the fat grafts were fragile and minimal trauma would jeopardize graft survival (1). Peer, in the 1950s, emphasized that the fat cells survived on diffusion for the first few days and by the fourth day neovascularization occurs (1). Injection volumes less than 3 mm in diameter were suggested by Carpaneta in 1994, since tissue nutrients only diffuse 1.5 mm (2).
