ABSTRACT
Thrombolytic and antithrombotic agents have been studied in a variety of clinical indications.
Issues arise in each clinical setting that are unique to trial design and the interpretation of results,
yet certain common principles should govern the design of clinical trials in all settings. This
chapter initially reviews general considerations that are common and pertinent to all clinical
trials with these agents. A discussion follows of some of the major design issues illustrated by
recent trial experiences in selected settings, including acute myocardial infarction, coronary
artery disease, acute ischemic stroke, and peripheral arterial occlusion.
