ABSTRACT
H1-receptor antagonists are frequently used during pregnancy and lactation (1). A major reason for this is that two of the diseases for which these antihistamines are often used, allergic rhinitis and upper respiratory infections, are common in women of child-bearing age. In addition, urticaria and atopic dermatitis, two other indications for H1-antihistamines, are not uncommon in this age group. Less commonly, antihistamines may be necessary as part of adjunctive therapy for life-threatening anaphylaxis during pregnancy. Therefore, the selection of antihistamines during pregnancy and lactation is an important clinical issue. In this chapter, we will first review general information and concepts regarding the use of medications during pregnancy. Next, the data available regarding the safety of specific antihistamines during pregnancy and lactation will be reviewed. Finally, based on this information, recommendations will be presented regarding the choice and clinical use of H1-receptor antagonists in the pregnant or lactating patient.
