ABSTRACT
Vascular changes after chronic hypoxia are characterized by hyperplasia, hypertrophy, and migration of smooth muscle cells (SMCs) in the media of muscular and partially muscular pulmonary arteries (1,2). A number of factors are known to cause SMC migration, such as serum, platelet-derived growth factor (PDGF)- BB (3,4), transforming growth factor-β (5), fibrinogen (6), oxidized low-density lipoprotein (7,8), and angiotensin II (9,10).
