Alzheimer’s disease (AD) is characterized by the insidious onset of cognitive deficits that progress over the course of several years. The nature of the cognitive impairments and their severity vary greatly throughout the various stages of the disease, some symptoms emerging early in the disease and others occurring in later stages. This chapter will review the main domains of cognition that can be impaired in AD over the course of the disease, including memory, language, executive functions, visuospatial skills and praxis, as well as the evolution of cognitive impairments over the course of the disease. Finally, a short section of this chapter will briefly review atypical presentations of AD, their main presenting cognitive features and their evolution.