ABSTRACT
Does apolipoprotein E (apoE) polymorphism matter? Yes in the case of amnestic MCI, where the risk of progression to a formal diagnosis of AD is greatly increased for carriers of apoE4 compared with apoE3.2 On the other hand, current guidelines do not advocate genotyping asymptomatic persons or patients with MCI for apoE status (Chapter 27). In patients with atypical presentations of dementia, this can be considered as an optional test, since dementia
Figure 29.1 The intensity of symptoms in various domains throughout the progression of Alzheimer’s disease
is more likely caused by AD in apoE4 carriers (Chapter 1).
