ABSTRACT
Aggressive symptoms encompass heterogeneous behaviors, ranging from milder temper tantrums and recurrent verbal aggression to self-injurious behaviors, serious physical assault, and destruction of objects. Aggressive symptoms in Tourette’s syndrome (TS) are common in clinical settings where approximately 25-70% of TS patients report anger control problems, irritability, and recurrent behavioral outbursts (1-6). In a descriptive study of 3500 individuals with TS surveyed worldwide using a multisite, international database,37%reportedahistoryofangercontrolproblemsand25%described current problems with anger control (4). An uncontrolled clinical study of
MD: KURLAN, JOB: 03329, PAGE:
64 TS patients in Japan reported aggressiveness and impulsivity in 48%, self-injurious behaviors in 20.3%, and domestic violence in nearly 11% (7).
