ABSTRACT
Noninvasive bioengineering methods permit sophisticated detection and
quantification of subclinical changes in skin physiology. Some methods have
become standard in specialized fields such as skin pharmacology, cosmetology,
and dermatological research. However, their application also can be beneficial
when studying the female genital area. Human vulvar skin is an example
of specialized skin, comprising keratinized epithelium and nonkeratinized
mucosa, accompanied by considerable underlying age-and hormone-related
changes throughout life. Exposure to humidity, occlusion, friction, and a particu-
lar microbial environment, coupled with the lack of UV exposure, contribute
to unique functional skin characteristics, such as a less-complete water barrier
function as compared to other body regions (1-3). Garments, shower gels,
soaps, moisturizers, deodorants, sanitary pads, as well as condoms may induce
subclinical skin irritation or even apparent contact dermatitis (4).
