ABSTRACT
The field of urological malignancies represents the combination of many medical specialties including oncology, urology, and other specialized surgeries in an attempt to provide a multidisciplinary approach to treatment. Testicular germ-cell tumors are remarkable in that they are uniquely sensitive to chemotherapeutic agents. The most frequently used regimen is the bleomycin, etoposide (BEP) and cisplatin. Nephrotoxicity is related to the use of cisplatin. Attempts have been made to reduce the nephrotoxic effects mainly by hydrating the patient during drug administration. Neuropathy also frequently results from the use of cisplatin-based regimens. Typically, patients with testicular cancer who receive the cisplatin-based regimens may experience neuropathy concurrent with the therapy and as late as three months after the completion of therapy. Cardiac toxicity is also associated with the BEP regimen. The main cardiac-associated toxicities include hypertension, atherosclerosis, coronary artery disease, and dyslipidemia.
