ABSTRACT
Carcinomas of an unknown primary (CUP) site represent about 3% to 5% of all cancer types (1-4). New local treatments have occurred in metastatic disease but there are a few specific CUP-related data. Several techniques will be developed in a broader framework. In this chapter, we will discuss
radiofrequency, which is now part of the local treatment of hepatic metastases, whereas extracerebral stereotactic radiotherapy should be initiated soon. Concerning bone metastases, a unique radiotherapy session allows the same antalgic effect and, as durable as hypofractioned patterns. Surgery, particularly in the preventive indications, plays an important role in the treatment of these secondary bone lesions. In the future, trials specific to CUP should be considered in order to better specify the indications and the efficiency of these treatments.
