ABSTRACT
Louise Brown, the first baby to come from in vitro fertilization (IVF) was born in 1978. In the > 25 years since that event, millions of babies have been born benefiting from infertility therapies including more than 1,000,000 IVF babies. These incredible success stories, however, have had corresponding serious side effects. The twin pregnancy rate, commonly quoted for decades to be 1 in 90, now has doubled to more than 1 in 45. About 70% of all twins in the United States have come from infertility treatments. Some IVF programs create as many multiples as singletons.
