Alzheimer’s disease (AD) is an age-related neurodegenerative disorder associated with

progressive functional decline, dementia, and neuronal loss. Demographics make evident

that the prevalence of AD will increase substantially. The pervasive societal burden

wrought by this debilitating disease should provide sufficient impetus for the development

of new natural history modifying therapeutic approaches. However, because the

mechanistic underpinnings of AD are incompletely understood, the clinical disease

spectrum broad, and the neuropathological features of its initiation and progression

limited, the development of such potential disease modifying therapies has been impeded.

Herein, we review AD pathophysiology and currently employed therapies, and

subsequently discuss experimental therapeutics predicated upon recent concepts of

immune modulation to attenuate disease progression.