ABSTRACT
Nevertheless, several shortcomings continue to limit the use of this modality. These limitations include (i) inherently low or non-gallium-avidity of several histological types of lymphomas, (ii) the spatial resolution capabilities of currently available gamma camera technology for detection of small lesions, (iii) the normal physiologic biodistribution of this radiotracer, and (iv) the nonspecific increased gallium uptake in benign or nonlymphomatous processes. Some of the latter drawbacks are enhanced by the inherent lack of clear anatomic detail of nuclear medicine images in general and GS in particular. Uncertainty in the anatomic localization of areas of increased tracer activity may hamper their characterization as normal or abnormal findings.
