ABSTRACT

The pathogenesis of peptic ulcers appears to be different from that of common stress ulcers. For example, common (“non-Cushing”) stress ulcers usually occur in the proximal stomach, whereas peptic ulcer lesions usually develop in the gastric antrum and in the duodenum. In addition, common “non-Cushing” stress ulcers are typically superficial and more numerous than peptic ulcer lesions. The shallow, diffuse stress ulcers typically result in clinically occult or mild bleeding. However, deeper ulcerated lesions can occur and lead to significant gross hemorrhage.