ABSTRACT
In order to provide optimal therapy for patients, a drug of choice and its accompanying dose and schedule must accomplish two ends. First and foremost, it must be efficacious. Secondly, it should optimally be nontoxic. While there are multiple types of toxicities, the kind that is subject to intervention is that where the likelihood of toxicity is related to the concentration of the drug. In this chapter, we will examine three different examples of toxicity linked to drug exposure and explore the implications for successful drug therapy.
